Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mair, B.; Popow, J.; Mechtler, K.; Weitzer, S.; Martinez, J.
    Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components (2013), Biochem. Soc. Trans., 41, 831-837.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.78 K127A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.78 ATP + 5'-dephospho-DNA Homo sapiens
-
 ADP + 5'-phospho-DNA
-
 ?
2.7.1.78 additional information Homo sapiens the enzyme plays a role in tRNA splicing. The ATP-binding and/or hydrolysis capacity of CLP1 is required to enhance pre-tRNA cleavage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.78 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.78 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.78 ATP + 5'-dephospho-DNA
-
 Homo sapiens ADP + 5'-phospho-DNA
-
 ?
2.7.1.78 additional information the enzyme plays a role in tRNA splicing. The ATP-binding and/or hydrolysis capacity of CLP1 is required to enhance pre-tRNA cleavage Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.78 cleavage and polyadenylation factor I subunit
-
 Homo sapiens
2.7.1.78 CLP1
-
 Homo sapiens
2.7.1.78 HEAB originally termed Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.78 malfunction the lack of CLP1 kinase activity leads to progressive motor neuron loss and accumulation of novel 5' leader-5' exon tRNA fragments Homo sapiens